Currently, R438-15-8 states that the second newborn screening shall be collected between 7 to 28 days of age. The Newborn Screening program proposed a change in the timing of collection of the second screen to 7 to 16 days of age. Data presented to the Newborn Screening Advisory Committee (NSAC) demonstrated the clinical importance of collecting a second screen sooner for certain disorders such as cystic fibrosis and congenital hypothyroidism. Shortening the collection window for the second newborn screen will help with meeting the goal for treatment by 21 days for these disorders. Additionally, this timeframe is in line with other 2-screen states that require second screens to be collected during an even shorter window (e.g. 8-14 days).